Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence

Epidermal growth factor receptor (EGFR) gene amplification is the most common genetic alteration in high-grade glioma, and ≈50% of EGFR-amplified tumors also harbor a constitutively active mutant form of the receptor, ΔEGFR. Although ΔEGFR greatly enhances tumor growth and is thus an attractive targ...

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Main Authors: Mukasa, Akitake, Wykosky, Jill, Ligon, Keith L., Chin, Lynda, Cavenee, Webster K., Furnari, Frank
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823874/
https://ncbi.nlm.nih.gov/pubmed/20133782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914356107
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