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Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence
Epidermal growth factor receptor (EGFR) gene amplification is the most common genetic alteration in high-grade glioma, and ≈50% of EGFR-amplified tumors also harbor a constitutively active mutant form of the receptor, ΔEGFR. Although ΔEGFR greatly enhances tumor growth and is thus an attractive targ...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823874/ https://ncbi.nlm.nih.gov/pubmed/20133782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914356107 |
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