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BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain
p53 can induce apoptosis through mitochondrial membrane permeabilization by interaction of its DNA binding region with the anti-apoptotic proteins BclxL and Bcl2. However, little is known about the action of p53 at the mitochondria in molecular detail. By using NMR spectroscopy and fluorescence pola...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823462/ https://ncbi.nlm.nih.gov/pubmed/19955567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065391 |
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