BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain

p53 can induce apoptosis through mitochondrial membrane permeabilization by interaction of its DNA binding region with the anti-apoptotic proteins BclxL and Bcl2. However, little is known about the action of p53 at the mitochondria in molecular detail. By using NMR spectroscopy and fluorescence pola...

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Bibliographic Details
Main Authors: Hagn, Franz, Klein, Christian, Demmer, Oliver, Marchenko, Natasha, Vaseva, Angelina, Moll, Ute M., Kessler, Horst
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823462/
https://ncbi.nlm.nih.gov/pubmed/19955567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065391
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