The Structure of Mammalian Serine Racemase: EVIDENCE FOR CONFORMATIONAL CHANGES UPON INHIBITOR BINDING

Serine racemase is responsible for the synthesis of d-serine, an endogenous co-agonist for N-methyl-d-aspartate receptor-type glutamate receptors (NMDARs). This pyridoxal 5′-phosphate-dependent enzyme is involved both in the reversible conversion of l- to d-serine and serine catabolism by α,β-elimin...

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Détails bibliographiques
Auteurs principaux: Smith, Myron A., Mack, Volker, Ebneth, Andreas, Moraes, Isabel, Felicetti, Brunella, Wood, Michael, Schonfeld, Dorian, Mather, Owen, Cesura, Andrea, Barker, John
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857111/
https://ncbi.nlm.nih.gov/pubmed/20106978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.050062
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