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Mammalian TIMELESS Is Required for ATM-dependent CHK2 Activation and G(2)/M Checkpoint Control
Timeless (Tim), a core circadian clock gene in Drosophila, is retained in mammals but has no apparent mammalian circadian clock function. Mammalian TIM is essential for ATR-dependent Chk1 activation and S-phase arrest. We report that TIM is likewise essential for ATM-dependent Chk2-mediated signalin...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823431/ https://ncbi.nlm.nih.gov/pubmed/19996108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.050237 |
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