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Large T Antigen Promotes JC Virus Replication in G(2)-arrested Cells by Inducing ATM- and ATR-mediated G(2) Checkpoint Signaling

Large T antigen (TAg) of the human polyomavirus JC virus (JCV) possesses DNA binding and helicase activities, which, together with various cellular proteins, are required for replication of the viral genome. We now show that JCV-infected cells expressing TAg accumulate in the G(2) phase of the cell...

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Detaylı Bibliyografya
Asıl Yazarlar: Orba, Yasuko, Suzuki, Tadaki, Makino, Yoshinori, Kubota, Kanako, Tanaka, Shinya, Kimura, Takashi, Sawa, Hirofumi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801279/
https://ncbi.nlm.nih.gov/pubmed/19903823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064311
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