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The Protein Kinase Cδ Catalytic Fragment Is Critical for Maintenance of the G(2)/M DNA Damage Checkpoint
Protein kinase Cδ (PKCδ) is an essential component of the intrinsic apoptotic program. Following DNA damage, such as exposure to UV radiation, PKCδ is cleaved in a caspase-dependent manner, generating a constitutively active catalytic fragment (PKCδ-cat), which is necessary and sufficient for kerati...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804346/ https://ncbi.nlm.nih.gov/pubmed/19917613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055392 |
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