Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response

To investigate drug mechanisms of action and identify molecular targets for the development of rational drug combinations, we conducted synthetic small interfering RNA (siRNA)-based RNAi screens to identify genes whose silencing affects anti-cancer drug responses. Silencing of RRM1 and RRM2, which e...

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Detalhes bibliográficos
Main Authors: Zhang, Yong-Wei, Jones, Tamara L., Martin, Scott E., Caplen, Natasha J., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709352/
https://ncbi.nlm.nih.gov/pubmed/19416980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.003020
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