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Autoinhibition and Autoactivation of the DNA Replication Checkpoint Kinase Cds1
Cds1 is the ortholog of Chk2 and the major effector of the DNA replication checkpoint in Schizosaccharomyces pombe. Previous studies have shown that Cds1 is activated by a two-stage mechanism. In the priming stage, the sensor kinase Rad3 and the mediator Mrc1 function to phosphorylate a threonine re...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708895/ https://ncbi.nlm.nih.gov/pubmed/19357077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900785200 |
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