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The Protein Kinase Cδ Catalytic Fragment Targets Mcl-1 for Degradation to Trigger Apoptosis
Proteolytic cleavage and subsequent activation of protein kinase C (PKC) δ is required for apoptosis induced by a variety of genotoxic agent, including UV radiation. In addition, overexpression of the constitutively active PKCδ catalytic fragment (PKCδ-cat) is sufficient to trigger Bax activation, c...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2205529/ https://ncbi.nlm.nih.gov/pubmed/16901898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607351200 |
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