Hypoxia Enhances the Replication of Oncolytic Herpes Simplex Virus

Hypoxia contributes to the resistance of tumors to conventional therapies. We hypothesized that their replication in hypoxic environments like brain or oral mucosa would make oncolytic herpes simplex viruses (HSVs) such as G207 (which has undergone clinical trials) replicate to a greater extent in h...

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Bibliographic Details
Main Authors: Aghi, Manish K, Liu, Ta-Chiang, Rabkin, Samuel, Martuza, Robert L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823294/
https://ncbi.nlm.nih.gov/pubmed/18957963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.232
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