Hypoxia Enhances the Replication of Oncolytic Herpes Simplex Virus

Hypoxia contributes to the resistance of tumors to conventional therapies. We hypothesized that their replication in hypoxic environments like brain or oral mucosa would make oncolytic herpes simplex viruses (HSVs) such as G207 (which has undergone clinical trials) replicate to a greater extent in h...

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Main Authors: Aghi, Manish K, Liu, Ta-Chiang, Rabkin, Samuel, Martuza, Robert L
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823294/
https://ncbi.nlm.nih.gov/pubmed/18957963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.232
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