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Hypoxia Enhances the Replication of Oncolytic Herpes Simplex Virus
Hypoxia contributes to the resistance of tumors to conventional therapies. We hypothesized that their replication in hypoxic environments like brain or oral mucosa would make oncolytic herpes simplex viruses (HSVs) such as G207 (which has undergone clinical trials) replicate to a greater extent in h...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823294/ https://ncbi.nlm.nih.gov/pubmed/18957963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.232 |
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