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Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS
At least two human APOBEC3 proteins – APOBEC3F and APOBEC3G – are capable of inhibiting HIV-1 replication by mutation of the viral cDNA. HIV-1 averts lethal restriction through its accessory protein Vif, which targets these APOBEC3 proteins for proteasomal degradation. The life-or-death interaction...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822356/ https://ncbi.nlm.nih.gov/pubmed/20174454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fvl.09.59 |
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