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Mechanism of DNA-Protein Crosslinking by Chromium

Hexavalent chromium is a known inducer of DNA-protein crosslinks (DPC) that contribute to repression of inducible genes and genotoxicity of this metal. Lymphocytic DPC have also shown potential utility as biomarkers of human exposure to Cr(VI). Here, we examined the mechanism of DPC formation by Cr(...

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Detalhes bibliográficos
Main Authors: Macfie, Andrea, Hagan, Elizabeth, Zhitkovich, Anatoly
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822107/
https://ncbi.nlm.nih.gov/pubmed/19877617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx9003402
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