15-deoxy-Δ(12,14) prostaglandin J(2)-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis

BACKGROUND: Platelet production is an intricate process that is poorly understood. Recently, we demonstrated that the natural PPARγ ligand, 15-deoxy-Δ(12,14) prostaglandin J(2) (15d-PGJ(2)), augments platelet production from megakaryocytes. 15d-PGJ(2) can exert effects independent of PPARγ, by incre...

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Autors principals: O’Brien, Jamie J., Baglole, Carolyn J., Garcia-Bates, Tatiana M., Blumberg, Neil, Francis, Charles W., Phipps, Richard P.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821682/
https://ncbi.nlm.nih.gov/pubmed/18983509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2008.03191.x
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