15-Deoxy-Δ(12,14)-prostaglandin J(2) Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells

BACKGROUND: Abnormal upregulation of prostaglandin E(2) (PGE(2)) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme catabolizing PGE(2), is ub...

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Veröffentlicht in:J Cancer Prev
Hauptverfasser: Park, Jong-Min, Na, Hye-Kyung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Society of Cancer Prevention 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786809/
https://ncbi.nlm.nih.gov/pubmed/31624724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15430/JCP.2019.24.3.183
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