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Oncogenic ras-induced Down-regulation of Autophagy Mediator Beclin-1 Is Required for Malignant Transformation of Intestinal Epithelial Cells

Detachment of non-malignant epithelial cells from the extracellular matrix causes their growth arrest and, ultimately, death. By contrast, cells composing carcinomas, cancers of epithelial origin, can survive and proliferate without being attached to the extracellular matrix. These properties of tum...

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Bibliografiske detaljer
Main Authors: Yoo, Byong Hoon, Wu, Xue, Li, Yongling, Haniff, Mehnaaz, Sasazuki, Takehiko, Shirasawa, Senji, Eskelinen, Eeva-Liisa, Rosen, Kirill V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820772/
https://ncbi.nlm.nih.gov/pubmed/19778902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046789
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