An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase

The interaction of factor Xa with factor Va on membranes to form prothrombinase profoundly increases the rate of the proteolytic conversion of prothrombin to thrombin. We present the characterization of an RNA aptamer (RNA(11F7t)) selected from a combinatorial library based on its ability to bind fa...

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Main Authors: Buddai, Sai K., Layzer, Juliana M., Lu, Genmin, Rusconi, Christopher P., Sullenger, Bruce A., Monroe, Dougald M., Krishnaswamy, Sriram
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820749/
https://ncbi.nlm.nih.gov/pubmed/20022942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049833
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