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Anti-PEG antibodies inhibit the anticoagulant activity of PEGylated aptamers

Biopharmaceuticals have become increasingly attractive therapeutic agents and are often PEGylated to enhance their pharmacokinetics and reduce their immunogenicity. However, recent human clinical trials have demonstrated that administration of PEGylated compounds can evoke anti-PEG antibodies. Consi...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Moreno, Angelo, Pitoc, George A., Ganson, Nancy J., Layzer, Juliana M., Hershfield, Michael S., Tarantal, Alice F., Sullenger, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707742/
https://ncbi.nlm.nih.gov/pubmed/30827937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.02.001
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