Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus

Antibodies that specifically bind polyethylene glycol (PEG) can lead to rapid elimination of PEGylated therapeutics from the systemic circulation. We have recently shown that virus-binding IgG can immobilize viruses in mucus via multiple low-affinity crosslinks between IgG and mucins. However, it re...

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Detalhes bibliográficos
Publicado no:Acta Biomater
Main Authors: Henry, Christine E., Wang, Ying-Ying, Yang, Qi, Hoang, Thuy, Chattopadhyay, Sumon, Hoen, Timothy, Ensign, Laura M., Nunn, Kenetta L., Schroeder, Holly, McCallen, Justin, Moench, Thomas, Cone, Richard, Roffler, Steve R., Lai, Samuel K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645030/
https://ncbi.nlm.nih.gov/pubmed/27424083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2016.07.019
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