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Anti-PEG antibodies in the clinic: current issues and beyond PEGylation
The technique of attaching the polymer polyethylene glycol (PEG), or PEGylation, has brought more than ten protein drugs into market. The surface conjugation of PEG on proteins prolongs their blood circulation time and reduces immunogenicity by increasing their hydrodynamic size and masking surface...
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| Veröffentlicht in: | J Control Release |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5747248/ https://ncbi.nlm.nih.gov/pubmed/27369864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.06.040 |
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