Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

Antibodies that specifically bind polyethylene glycol (PEG), i.e. anti-PEG antibodies (APA), are associated with reduced efficacy and increased risk of serious adverse events for several PEGylated therapeutics. Here, we explored the concept of using free PEG molecules to saturate circulating APA. Su...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: McSweeney, Morgan D., Price, Lauren S.L., Wessler, Timothy, Ciociola, Elizabeth C., Herity, Leah B., Piscitelli, Joseph A., DeWalle, Alexander C., Harris, Taylor N., Chan, Andy K.P., Saw, Ran Sing, Hu, Peiqi, Jennette, J. Charles, Forest, M. Gregory, Cao, Yanguang, Montgomery, Stephanie A., Zamboni, William C., Lai, Samuel K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874909/
https://ncbi.nlm.nih.gov/pubmed/31454530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.08.017
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