Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

Antibodies that specifically bind polyethylene glycol (PEG), i.e. anti-PEG antibodies (APA), are associated with reduced efficacy and increased risk of serious adverse events for several PEGylated therapeutics. Here, we explored the concept of using free PEG molecules to saturate circulating APA. Su...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: McSweeney, Morgan D., Price, Lauren S.L., Wessler, Timothy, Ciociola, Elizabeth C., Herity, Leah B., Piscitelli, Joseph A., DeWalle, Alexander C., Harris, Taylor N., Chan, Andy K.P., Saw, Ran Sing, Hu, Peiqi, Jennette, J. Charles, Forest, M. Gregory, Cao, Yanguang, Montgomery, Stephanie A., Zamboni, William C., Lai, Samuel K.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874909/
https://ncbi.nlm.nih.gov/pubmed/31454530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.08.017
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker