Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

Antibodies that specifically bind polyethylene glycol (PEG), i.e. anti-PEG antibodies (APA), are associated with reduced efficacy and increased risk of serious adverse events for several PEGylated therapeutics. Here, we explored the concept of using free PEG molecules to saturate circulating APA. Su...

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Veröffentlicht in:J Control Release
Hauptverfasser: McSweeney, Morgan D., Price, Lauren S.L., Wessler, Timothy, Ciociola, Elizabeth C., Herity, Leah B., Piscitelli, Joseph A., DeWalle, Alexander C., Harris, Taylor N., Chan, Andy K.P., Saw, Ran Sing, Hu, Peiqi, Jennette, J. Charles, Forest, M. Gregory, Cao, Yanguang, Montgomery, Stephanie A., Zamboni, William C., Lai, Samuel K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874909/
https://ncbi.nlm.nih.gov/pubmed/31454530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.08.017
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