Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice

Immune responses against polyethylene glycol (PEG) can lead to the rapid clearance of PEGylated drugs and are associated with increased risk of serious adverse events such as infusion reactions and anaphylaxis. Although select PEGylated therapeutics can induce anti-PEG antibodies (APA), there is cur...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Control Release
Egile Nagusiak: McSweeney, Morgan D., Shen, Limei, DeWalle, Alexander C., Joiner, Jordan B., Ciociola, Elizabeth C., Raghuwanshi, Dharmendra, Macauley, Matthew S., Lai, Samuel K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904660/
https://ncbi.nlm.nih.gov/pubmed/33038448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.10.011
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