Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice

Immune responses against polyethylene glycol (PEG) can lead to the rapid clearance of PEGylated drugs and are associated with increased risk of serious adverse events such as infusion reactions and anaphylaxis. Although select PEGylated therapeutics can induce anti-PEG antibodies (APA), there is cur...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: McSweeney, Morgan D., Shen, Limei, DeWalle, Alexander C., Joiner, Jordan B., Ciociola, Elizabeth C., Raghuwanshi, Dharmendra, Macauley, Matthew S., Lai, Samuel K.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904660/
https://ncbi.nlm.nih.gov/pubmed/33038448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.10.011
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker