Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice

Immune responses against polyethylene glycol (PEG) can lead to the rapid clearance of PEGylated drugs and are associated with increased risk of serious adverse events such as infusion reactions and anaphylaxis. Although select PEGylated therapeutics can induce anti-PEG antibodies (APA), there is cur...

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Detaylı Bibliyografya
Yayımlandı:J Control Release
Asıl Yazarlar: McSweeney, Morgan D., Shen, Limei, DeWalle, Alexander C., Joiner, Jordan B., Ciociola, Elizabeth C., Raghuwanshi, Dharmendra, Macauley, Matthew S., Lai, Samuel K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904660/
https://ncbi.nlm.nih.gov/pubmed/33038448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.10.011
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