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Potent Anticoagulant Aptamer Directed against Factor IXa Blocks Macromolecular Substrate Interaction
An aptamer targeting factor IXa has been evaluated in animal models and several clinical studies as a potential antithombotic therapy. We elucidate the molecular mechanism by which this aptamer acts as an anticoagulant. The aptamer binds tightly to factor IXa and prolongs the clotting time of human...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340003/ https://ncbi.nlm.nih.gov/pubmed/22334679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300772 |
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