High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

BACKGROUND: Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Azorsa, David O, Robeson, RiLee H, Frost, Danielle, hoovet, Bessie Meec, Brautigam, Gillian R, Dickey, Chad, Beaudry, Christian, Basu, Gargi D, Holz, David R, Hernandez, Joseph A, Bisanz, Kristen M, Gwinn, Leslie, Grover, Andrew, Rogers, Joseph, Reiman, Eric M, Hutton, Michael, Stephan, Dietrich A, Mousses, Spyro, Dunckley, Travis
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2010
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820455/
https://ncbi.nlm.nih.gov/pubmed/20067632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-25
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