High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

BACKGROUND: Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-...

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Detaylı Bibliyografya
Asıl Yazarlar: Azorsa, David O, Robeson, RiLee H, Frost, Danielle, hoovet, Bessie Meec, Brautigam, Gillian R, Dickey, Chad, Beaudry, Christian, Basu, Gargi D, Holz, David R, Hernandez, Joseph A, Bisanz, Kristen M, Gwinn, Leslie, Grover, Andrew, Rogers, Joseph, Reiman, Eric M, Hutton, Michael, Stephan, Dietrich A, Mousses, Spyro, Dunckley, Travis
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820455/
https://ncbi.nlm.nih.gov/pubmed/20067632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-25
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