High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

BACKGROUND: Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-...

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Detalhes bibliográficos
Main Authors: Azorsa, David O, Robeson, RiLee H, Frost, Danielle, hoovet, Bessie Meec, Brautigam, Gillian R, Dickey, Chad, Beaudry, Christian, Basu, Gargi D, Holz, David R, Hernandez, Joseph A, Bisanz, Kristen M, Gwinn, Leslie, Grover, Andrew, Rogers, Joseph, Reiman, Eric M, Hutton, Michael, Stephan, Dietrich A, Mousses, Spyro, Dunckley, Travis
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820455/
https://ncbi.nlm.nih.gov/pubmed/20067632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-25
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