High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

BACKGROUND: Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-...

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Autori principali: Azorsa, David O, Robeson, RiLee H, Frost, Danielle, hoovet, Bessie Meec, Brautigam, Gillian R, Dickey, Chad, Beaudry, Christian, Basu, Gargi D, Holz, David R, Hernandez, Joseph A, Bisanz, Kristen M, Gwinn, Leslie, Grover, Andrew, Rogers, Joseph, Reiman, Eric M, Hutton, Michael, Stephan, Dietrich A, Mousses, Spyro, Dunckley, Travis
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820455/
https://ncbi.nlm.nih.gov/pubmed/20067632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-25
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