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Treatment Strategies Targeting Excess Hippocampal Activity Benefit Aged Rats with Cognitive Impairment

Excess neural activity in the CA3 region of the hippocampus has been linked to memory impairment in aged rats. We tested whether interventions aimed at reducing this excess activity would improve memory performance. Aged (24 to 28 months old) male Long–Evans rats were characterized in a spatial memo...

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Détails bibliographiques
Auteurs principaux: Koh, Ming Teng, Haberman, Rebecca P, Foti, Stacey, McCown, Thomas J, Gallagher, Michela
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820138/
https://ncbi.nlm.nih.gov/pubmed/20032967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.207
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