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Treatment Strategies Targeting Excess Hippocampal Activity Benefit Aged Rats with Cognitive Impairment

Excess neural activity in the CA3 region of the hippocampus has been linked to memory impairment in aged rats. We tested whether interventions aimed at reducing this excess activity would improve memory performance. Aged (24 to 28 months old) male Long–Evans rats were characterized in a spatial memo...

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Detalhes bibliográficos
Main Authors: Koh, Ming Teng, Haberman, Rebecca P, Foti, Stacey, McCown, Thomas J, Gallagher, Michela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820138/
https://ncbi.nlm.nih.gov/pubmed/20032967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.207
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