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Comparison of Akt/mTOR Signaling in Primary Breast Tumors and Matched Distant Metastases

BACKGROUND: The Akt/mammalian target of the rapamycin (mTOR) signaling pathway represents a promising target for cancer therapy. The phosphorylation status of Akt and of mTOR's phosphorylation target eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is often used to assess the activity...

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Autors principals: Akcakanat, Argun, Sahin, Aysegul, Shaye, Alexandra N., Velasco, Marco A., Meric-Bernstam, Funda
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819051/
https://ncbi.nlm.nih.gov/pubmed/18386830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.23456
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