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Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-Å structure of the ternary complex
Factor (f) IXa is a critical enzyme for the formation of stable blood clots, and its deficiency results in hemophilia. The enzyme functions at the confluence of the intrinsic and extrinsic pathways by binding to fVIIIa and rapidly generating fXa. In spite of its importance, little is known about how...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818950/ https://ncbi.nlm.nih.gov/pubmed/20080729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910144107 |
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