Aglycosylated IgG variants expressed in bacteria that selectively bind FcγRI potentiate tumor cell killing by monocyte-dendritic cells

The N-linked glycan of immunoglobulin G (IgG) is indispensable for the interaction of the Fc domain with Fcγ receptors on effector cells and the clearance of target cells via antibody dependent cell-mediated cytotoxicity (ADCC). Escherichia coli expressed, aglycosylated Fc domains bind effector FcγR...

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Main Authors: Jung, Sang Taek, Reddy, Sai T., Kang, Tae Hyun, Borrok, M. Jack, Sandlie, Inger, Tucker, Philip W., Georgiou, George
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2010
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818909/
https://ncbi.nlm.nih.gov/pubmed/20080725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908590107
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