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Revisiting the Role of Glycosylation in the Structure of Human IgG Fc
Binding of the Fc domain of Immunoglobulin G (IgG) to Fcγ receptors on leukocytes can initiate a series of signaling events resulting in antibody-dependent cell-mediated cytotoxicity (ADCC) and other important immune responses. Fc domains lacking glycosylation at N297 have greatly diminished Fcγ rec...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3448853/ https://ncbi.nlm.nih.gov/pubmed/22747430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300130k |
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