Aglycosylated IgG variants expressed in bacteria that selectively bind FcγRI potentiate tumor cell killing by monocyte-dendritic cells

The N-linked glycan of immunoglobulin G (IgG) is indispensable for the interaction of the Fc domain with Fcγ receptors on effector cells and the clearance of target cells via antibody dependent cell-mediated cytotoxicity (ADCC). Escherichia coli expressed, aglycosylated Fc domains bind effector FcγR...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Jung, Sang Taek, Reddy, Sai T., Kang, Tae Hyun, Borrok, M. Jack, Sandlie, Inger, Tucker, Philip W., Georgiou, George
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818909/
https://ncbi.nlm.nih.gov/pubmed/20080725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908590107
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker