MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells

BACKGROUND: Cancer cells utilize a variety of mechanisms to evade immune detection and attack. Effective immune detection largely relies on the formation of an immune synapse which requires close contact between immune cells and their targets. Here, we show that MUC16, a heavily glycosylated 3-5 mil...

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Autors principals: Gubbels, Jennifer AA, Felder, Mildred, Horibata, Sachi, Belisle, Jennifer A, Kapur, Arvinder, Holden, Helen, Petrie, Sarah, Migneault, Martine, Rancourt, Claudine, Connor, Joseph P, Patankar, Manish S
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818693/
https://ncbi.nlm.nih.gov/pubmed/20089172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-11
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