Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

BACKGROUND: The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors. The biochemical basis and the kinetics of the binding between these two glycoproteins are not clearly understood. Here we have addressed th...

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Autors principals: Gubbels, Jennifer AA, Belisle, Jennifer, Onda, Masanori, Rancourt, Claudine, Migneault, Martine, Ho, Mitchell, Bera, Tapan K, Connor, Joseph, Sathyanarayana, Bangalore K, Lee, Byungkook, Pastan, Ira, Patankar, Manish S
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635730/
https://ncbi.nlm.nih.gov/pubmed/17067392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-5-50
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