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Identification of novel agonists of the integrin CD11b/CD18

We report the identification of novel small molecule agonists of integrin CD11b/CD18, which increased, in a dose-dependent manner, the adhesion of the integrin CD11b/CD18 expressing cells to two physiologically relevant ligands: Fibrinogen and iC3b. Compound 6 showed an ex vivo EC(50) of 10.5 μM and...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Faridi, Mohd. Hafeez, Maiguel, Dony, Barth, Constantinos J., Stoub, Darren, Day, Ruth, Schürer, Stephan, Gupta, Vineet
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818319/
https://ncbi.nlm.nih.gov/pubmed/19879752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.077
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