Purification of ras GTPase activating protein from bovine brain.

In cytosolic extracts of bovine brain, we detected ras GTPase activating protein (GAP) activity that stimulated the GTP hydrolytic activity of normal c-Ha-ras p21 but not that of the oncogenic [Val12]p21 variant. GAP was purified 19,500-fold by a five-column procedure involving DEAE-Sephacel, Sephar...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Gibbs, J B, Schaber, M D, Allard, W J, Sigal, I S, Scolnick, E M
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1988
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281680/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3293047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.14.5026
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