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Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other. We show that the intracellular juxtamembrane segment of the receptor, known to potentiate kinase activity, is able to dimerize the kinase...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814540/ https://ncbi.nlm.nih.gov/pubmed/19563760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.04.025 |
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