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A New Reaction Motif: “Homo-S(N)2′-Like” Direct Nucleophilic Addition to Neutral η(3)-Allylmolybdenum Complexes. Total Synthesis of the Antimalarial (+)–Isofebrifugine

[Image: see text] Charge neutral TpMo(CO)(2)(5-acyloxy-η(3)-pyranyl) and TpMo(CO)(2)(5-acyloxy-η(3)-pyridinyl) scaffolds undergo a novel intermolecular “homo-S(N)2′-like” reaction with a variety of carbon nucleophiles. Combined with an annulative demetalation, the homo-S(N)2′-like substitution/annul...

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Detalhes bibliográficos
Main Authors: Chen, Wenyong, Liebeskind, Lanny S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814099/
https://ncbi.nlm.nih.gov/pubmed/19678704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9056322
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