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In Vivo Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists [(11)C]A-582941 and [(11)C]A-844606 in Mice and Conscious Monkeys

BACKGROUND: The α7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. The goal of this study was to evaluate the two carbon-11-labeled α7 nAChR agonists [(11)C]A-582941 and [(11)C]A...

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Detalhes bibliográficos
Main Authors: Toyohara, Jun, Ishiwata, Kiichi, Sakata, Muneyuki, Wu, Jin, Nishiyama, Shingo, Tsukada, Hideo, Hashimoto, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813863/
https://ncbi.nlm.nih.gov/pubmed/20126539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008961
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