Muscarinic Receptor Occupancy and Cognitive Impairment: A PET Study with [(11)C](+)3-MPB and Scopolamine in Conscious Monkeys

The muscarinic cholinergic receptor (mAChR) antagonist scopolamine was used to induce transient cognitive impairment in monkeys trained in a delayed matching to sample task. The temporal relationship between the occupancy level of central mAChRs and cognitive impairment was determined. Three conscio...

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Bibliografiske detaljer
Main Authors: Yamamoto, Shigeyuki, Nishiyama, Shingo, Kawamata, Masahiro, Ohba, Hiroyuki, Wakuda, Tomoyasu, Takei, Nori, Tsukada, Hideo, Domino, Edward F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096814/
https://ncbi.nlm.nih.gov/pubmed/21430646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.31
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