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Total Synthesis of (−)-Platensimycin, a Novel Antibacterial Agent

An enantioselective synthesis of platensimycin, a novel antibiotic natural product that inhibits bacterial β-ketoacyl-(acyl-carrier-protein) synthase (FabF), is described. Our synthetic strategy for the construction of the oxatetracyclic core involved an intramolecular Diels-Alder reaction. Our prel...

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Bibliografiske detaljer
Main Authors: Ghosh, Arun K., Xi, Kai
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812928/
https://ncbi.nlm.nih.gov/pubmed/19123842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo802261f
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