Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

Lymphocyte egress from lymph nodes (LNs) is dependent on sphingosine-1-phosphate (S1P), but the cellular source of this S1P is not defined. We generated mice that expressed Cre from the lymphatic vessel endothelial hyaluronan receptor 1 (Lyve-1) locus and that showed efficient recombination of loxP-...

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Autori principali: Pham, Trung H.M., Baluk, Peter, Xu, Ying, Grigorova, Irina, Bankovich, Alex J., Pappu, Rajita, Coughlin, Shaun R., McDonald, Donald M., Schwab, Susan R., Cyster, Jason G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2010
Soggetti:
Brief Definitive Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812554/
https://ncbi.nlm.nih.gov/pubmed/20026661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091619
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