B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Engagement of cytokine receptors by specific ligands activate Janus kinase–signal transducer and activator of transcription (STAT) signaling pathways. The exact roles of STATs in human lymphocyte behavior remain incompletely defined. Interleukin (IL)-21 activates STAT1 and STAT3 and has emerged as a...

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Main Authors: Avery, Danielle T., Deenick, Elissa K., Ma, Cindy S., Suryani, Santi, Simpson, Nicholas, Chew, Gary Y., Chan, Tyani D., Palendira, Umamainthan, Bustamante, Jacinta, Boisson-Dupuis, Stéphanie, Choo, Sharon, Bleasel, Karl E., Peake, Jane, King, Cecile, French, Martyn A., Engelhard, Dan, Al-Hajjar, Sami, Al-Muhsen, Saleh, Magdorf, Klaus, Roesler, Joachim, Arkwright, Peter D., Hissaria, Pravin, Riminton, D. Sean, Wong, Melanie, Brink, Robert, Fulcher, David A., Casanova, Jean-Laurent, Cook, Matthew C., Tangye, Stuart G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812540/
https://ncbi.nlm.nih.gov/pubmed/20048285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091706
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