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Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass
Protein kinase B (PKB)/Akt is considered to be a key target downstream of insulin receptor substrate 2 (IRS2) in the regulation of β-cell mass. However, while deficiency of IRS2 in mice results in diabetes with insulin resistance and severe failure of β-cell mass and function, only loss of the PKBβ...
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| Hlavní autoři: | , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology (ASM)
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812230/ https://ncbi.nlm.nih.gov/pubmed/19933838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00719-09 |
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