Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass

Protein kinase B (PKB)/Akt is considered to be a key target downstream of insulin receptor substrate 2 (IRS2) in the regulation of β-cell mass. However, while deficiency of IRS2 in mice results in diabetes with insulin resistance and severe failure of β-cell mass and function, only loss of the PKBβ...

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Main Authors: Buzzi, Francesca, Xu, Linhua, Zuellig, Richard A., Boller, Simone B., Spinas, Giatgen A., Hynx, Debby, Chang, Zai, Yang, Zhongzhou, Hemmings, Brian A., Tschopp, Oliver, Niessen, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812230/
https://ncbi.nlm.nih.gov/pubmed/19933838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00719-09
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